Is it better to take steroids in the morning or at night? by Drugs.com If you are taking Prednisone just once a day, take it in the morning with breakfast. The morning is best as it mimics the timing of your body's own production of cortisone. Taking your dose of prednisone too late in the evening may cause difficulty sleeping. What medications should not be taken with predniSONE? Types of drugs that are known to interact with prednisone include: Blood thinners, such as warfarin (Coumadin) Certain antifungal drugs, such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral) The nausea medication aprepitant (Emend) Aspirin. Can prednisone cause insomnia? Prednisone dose is causing lack of sleep. Dear Dr. Roach. Prednisone is a powerful anti-inflammatory and immune-system suppressor that is used for many conditions. It can cause some degree of insomnia in 50 to 70 percent of those who take it, but the higher the dose, the more likely the insomnia. What are the benefits of taking prednisone? "Prednisone is an anti-inflammatory drug that reduces the body's immune response in order to manage many different health conditions, including breathing problems, severe allergies, inflamed skin, serious eye swelling, serious arthritis, bowel disorders, blood disorders and certain cancers," said Tomaka.
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